SYSTEMIC IMMUNOREGULATORY CONSEQUENCES OF GUT COMMENSAL TRANSLOCATION
REVIEW PUBLISHED IN TRENDS IN IMMUNOLOGY (MEISEL LAB)
January, 2021
One major determinant of systemic immunity during homeostasis and in certain complex multifactorial diseases (e.g. cancer and autoimmune conditions), is the gut microbiota. These commensals can shape systemic immune responses via translocation of metabolites, microbial cell wall components, and viable microbes. In the last few years, bacterial translocation has revealed itself as playing a key, and potentially causal role in mediating immunomodulatory processes in nongastrointestinal diseases. Moreover, recent observations regarding the presence of complex microbial communities and viable bacteria within gut-distal tissues during homeostasis challenge the current paradigm that healthy mammals are entirely sterile at nonmucosal sites. This review discusses our current understanding of how the gut microbiota orchestrates systemic immunity during noninfectious extraintestinal diseases and homeostasis, focusing on the translocation of viable bacteria to gut-distal sites.
LAB BUBBLE TEA
CAN MICROBES BOOST TREGS TO SUPPRESS FOOD SENSITIVITIES?
REVIEW PUBLISHED IN TRENDS IN IMMUNOLOGY
October, 2020
Food sensitivities are on the rise worldwide. Peripheral induced regulatory T cells (pTreg cells) play a central role in oral tolerance to dietary antigens and can contribute to preventing the onset of immune-mediated food sensitivities. Here, we discuss the potential of microbial-derived products in promoting pTreg cell proliferation for re-establishing oral tolerance in immune-mediated food sensitivities.
WELCOME NEW LAB MEMBER ALEX MCPHERSON
Alex (Graduate Student) recently joined the Meisel Lab
June, 2020
GLOBAL GRANT FOR GUT HEALTH
The Hinterleitner Lab receives a grant supported by Nature Research & Yakult to advance understanding of the mechanisms by which gut microbes impact on human health
April, 2020
LENA’S FAREWELL DINNER
After a very productive year in the lab Lena is saying goodby to defend her Master thesis at the University of Vienna, Austria. We will miss her - First Lab Alumni!
February 2020
HAPPY HALLOWEEN
Mouse studies and translational research :)
November 2019
IMMUNOLOGY SCIENTIFIC RETREAT
Interesting talks and fun games at this years retreat. Group photo of the Meisel and Hinterleitner Labs
October 2019
WELCOME NEW LAB MEMBER YANLIN ZENG
Visiting research fellow from Tsinghua University School of Medicine, China
October 2019
WELCOME NEW LAB MEMBER CHHAVI GOEL
Postdoctoral research fellow
September 2019
WELCOME ROTATION STUDENTS FROM TSINGHUA UNIVERSITY SCHOOL OF MEDICINE, CHINA
Qixing Liu (Meisel Lab) and Yanlin Zeng (Hinterleitner Lab) will rotate in our labs for a couple of weeks. Hope you gain a lot of research experience and eventually join us for two years to work on exciting immunology/cancer projects!
August 2019
BASEBALL GAME WITH THE LAB
Baseball Game with the lab to welcome new lab members Mackenzie (Research technician) and Surya (Postdoc) and to celebrate the recent funding to work on exciting cancer related projects
July 2019
CANCER RESEARCH FUND
The Meisel Lab receives the UPMC Hillman Cancer Pilot and Feasibility Award
July 2019
CHILLING IN THE SUN
Enjoying the sun with a milkshake to celebrate the first grant for the Meisel Lab
June 2019
LIVER DISEASE RESEARCH FUND
The Meisel Lab receives the Pittsburgh Liver Research Pilot & Feasibility Grant
May 2019
WELCOME NEW LAB MEMBER MAGDALENA
Welcome Dinner for Magdalena, Austrian Marshall Plan Foundation Master Student
March 2019
CANCER RESEARCH FUND
The Hinterleitner Lab receives the UPMC Hillman Cancer Pilot and Feasibility Award
February 2019